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Location:Home-Product- >> Antimicrobial Agent >> NOVARON

NOVARON

NOVARON is a silver-supported antimicrobial agent in an inorganic ion exchanger, which our company uniquely developed. Novaron has an antimicrobial effect against a broad spectrum of microbes. It has uniform fine particles, low moisture absorption, and superior heat resistance. Novaron can be easily mixed into textiles, films, molded plastic products. It can also be dispersed easily in paints.
In addition, it has high physical and chemical stability. It has superior coloration and discoloration resistance during processing or use.
It is highly safe and has been approved by the U.S. FDA (Food and Drug Administration).

(1)Representative grades of NOVARON and its characteristics

 

Appearance

Average
particle diameter(μm)

Specific
gravity

Bulk spe-
cific gravity

AG 300

White powder

0.9

3.0

0.20-0.30

AGZ 330

White powder

1.3

4.2

0.25-0.35

AGT 330

White powder

0.4

4.4

0.50-0.60

 

 

 

 

(2)Representative grades of NOVARON and its application fields

Applications

AG300

AGZ330

AGT330

 

Molded plastic products

Opaque
(PP, PE, ABS, PS, PU, nylon, PBT, and POM)

 

 

Transparent
(PP, PE, AS, PS, PMMA, PET, and PC)

  

Molded film products

 

PVC

 

Textiles

PET and nylon

  

PP and PE

 

Coating process

Wood, leather, and paper

 

(Natural) textiles and non-woven fabrics

 

 

Ceramics and enamel

 

 

Paints

Transparent

 

 

Opaque

 

 

 

 

 

 

 

 

 

 

 


1 For the raw materials, the antimicrobial properties, durability, and discoloration can differ by manufacturer and grade.
2 Refer to technical documents for the appropriate grade for representative properties and characteristics of
NOVARON.

(3)Antimicrobial effect of NOVARON
The antimicrobial effects of
NOVARON have been confirmed against a broad spectrum of microbes.
The table below shows the minimum inhibition concentrations (MICs) of
NOVARON for various microbes. MIC shows the minimal concentration of antimicrobial agent to inhibit the growth and proliferation of microbes. A lower MIC value indicates a higher antimicrobial effect against that microbe.

Tested microbes

Characteristics

AG300

AGZ330

Escherichia coliBacteria which indicate contamination of food or drinking water125125

Escherichia coli
O157H7

Bacteria produce verotoxin and cause food poisoning.

200

200

Pseudomonas
aeruginosa

Pathogenic bacteria which cause decomposition of seafood

125

250

Salmonella

Pathogenic bacteria of abdominal typhus, paratyphoid, and food poisoning

250

250

Staphylococcus
aureus

Pathogenic bacteria of suppuration, sepsis, and food poisoning

250

250

MRSA

Pathogenic bacteria of nosocomial infection

250

250

Bacillus subtilis

Major bacteria causing decomposition of milk and meats

250

250

Candida albicans

Pathogenic yeast of candidaisis

500

250

Saccharomyces
cerevisiae

Yeast used in beer factories

500

250

Cladosporium

Typical mold which multiply in a normal living environment

500

500

Aspergillus
(Aspergillus niger)

Typical mold which multiply in a normal living environment

1000

500

(4)Safety of NOVARON
The high safety of
NOVARON has been confirmed in various clinical trials. In addition, it has been approved by the U.S. FDA (Food and Drug Administration). It can be used safely on food packaging.

Results of safety tests for NOVARON

Tested items

Test conditions

AG300

AGZ330

Sodium
chloride NaCl

Acute oral
toxicity LD50

OECD rats

>5,000mg/kg

>5,000mg/kg

3,000mg/kg

Mutagenicity

Guidelines of
safety and health
of Ministry of Health,
Labour and
Welfare

Negative

Negative

Negative

Primary skin
irritation

OECD rabbits

No irritation
observed

No irritation
observed

No irritation
observed

Skin
sensitization

OECD guinea pigs

Negative

Negative

Negative

Cytotoxicity
IC50

Japanese phar
macopeia,
13th edition

69~88μg/ml

27~40μg/ml

 

 

 

 

 

 

 

 

 

 


(5) Drug resistance test of NOVARON
When a certain type of drug is used repeatedly, drug resistant bacteria can emerge. The appearance of MRSA (methicillin resistant Staphylococcus aureus) is well known after repeated use of methicillin antibiotics. In the drug resistance tests, Novaron has been confirmed to possess properties that make the emergence of resistant bacteria more difficult.

(6)Heat resistance of NOVARON
The antimicrobial effect of
NOVARON does not change with heating of up to 800℃.

(7)Examples of applications of NOVARON

1.Applications in textiles
Fiber can be spun even for fine fibers
The average particle diameter of
NOVARON is approximately 1 mm. These fine particles have good uniformity. NOVARON is made from a material that does not easily absorb moisture. It is an inorganic antimicrobial agent suitable for mixing into the processing of fine fibers.

Laundering durability test

2>

No laundering

Laundered
10 times

Bacterial count at the commencement
of antimicrobial test

1.9×1044

Bacterial count
18 hours after
antimicrobial tests
commenced

Standard
unprocessed white cloth

2.4×107

-

Polyester fabric with
0.5% Novaron AG300 added

<20

<20

Polyester fabric
with 0.5% silverglass added

<20

1.7×107

Laundering durability test: JIS L-0217-103 method
Antimicrobial testing method: JIS L-1902-1998
Tested bacteria: Staphylococcus aureus

Suitable for coating process
NOVARON can be coated on materials into which NOVARON cannot be mixed such as wood, leather, and natural fibers.
Antimicrobial test of non-woven fabric coated with NOVARON

Bacterial count at the
commencement of antimicrobial test

2.1×104

Bacterial count 18 hours
after antimicrobial
tests commenced

Standard unprocessed
white cloth

2.5×107

Non-woven fabric
with no Novaron

1.8×107

Non-woven fabric coated
with Novaron

<20

Processing method: Acrylic binders are used on the non-woven fabrics, and 0.5 g/m2 of Novaron AG300 is use to coat the fabric.
Antimicrobial testing method: JIS L-1902-1998
Tested bacteria: Staphylococcus aureus

2.Applications to molded products

Antimicrobial ability can be easily attained with NOVARON
NOVARON
is made from uniform fine particles and is physically and chemically stable. Therefore, moldability and properties of resin are retained. It can be added by many different methods such as direct addition to resin and masterbatch process.

Antimicrobial effect of PE resin with NOVARON
Antimicrobial effect of PE resin with Novaron

Moldable even as thin film
Since NOVARON is made of uniform fine particles, its thin film can be molded smoothly.
Antimicrobial test of PE film (10 mm) with NOVARON

 

E. coli

Bacterial count at the
commencement of antimicrobial test

2.7×105

Bacterial count 18
hours after
antimicrobial tests
commenced

Film adhesion method *

1.5×107

Without Novaron

1.4×107

0.2% of Novaron AG110 added

<20

Processing method: Films are molded by mixing NOVARON into LDPE resin.
Antimicrobial testing method: Film adhesion method (Society of Industrial technology for Antimicrobial Articles)
*Control sample: polyethylene film was used.

Superior weather resistance
NOVARON is a physically and chemically stable material. Therefore, a molded product to which NOVARON is added retains its weather resistance.


Suitable for transparent resins
The NOVARON AG series is made of fine particles and has a refractive index close to many transparent resins. Therefore, resins made from the NOVARON AG series maintain their transparency.

(9)NOVARON and Society of Industrial technology for Antimicrobial Articles
The objectives of the Society of Industrial technology for Antimicrobial Articles are: (1) the establishment of standardized guidelines on performance and safety of antimicrobial agents and antimicrobial products; and (2) maintenance and dissemination of better quality and safer products. Novaron is a product that was designed based on the independent standards of this society, and Novaron has obtained the self-signed certification (SIAA symbol) of this society.

 

SIAA

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